A Good Molecule In Peanuts And Red Wine For Obese People

A Good Molecule In Peanuts And Red Wine For Obese People

Obesity, cancer, memory problems … Alone or associated with orange hesperidin, resveratrol has many virtues.

Resveratrol is a polyphenol naturally present in foods such as red grapes, raspberries, dark chocolate and red wine. Red wine contains between 0.02 and 0.58 mg of resveratrol per 100 mL, depending on the variety of grapes, chocolate 0.035 to 0.185 mg per 100 g, roasted peanuts contain 0.55 mg / 100 g and Peanut butter 3.25 mg / 100 g (one of the richest foods in resveratrol). Resveratrol also exists in the form of dietary supplements.

Associated with an orange compound, resveratrol improves the health of obese people

Oranges and red grapes contain compounds capable of controlling diseases related to obesity, including type 2 diabetes and cardiovascular disease. Two molecules present in orange and grape – hesperetin (hesperidin metabolite) and trans-resveratrol – when they are associated respectively have a beneficial effect on glycemia, the action of insulin And arterial health.

Overweight or obese people have an increased risk of insulin resistance, problems with glycemia control and cardiovascular disease.

People with obesity or type 2 diabetes have high concentrations of methylglyoxal, a powerful glycation agent derived from sugar. Methylglyoxal alters proteins by glycation and has adverse effects on metabolic health – including insulin and vascular resistance.

In this study, the researchers hypothesized that by increasing the expression of an enzyme, glyoxalase 1 (Glo1) – whose role is to neutralize the harmful effects of methylglyoxal-, they could improve metabolic and vascular health In obese patients. In fact, when combined, trans-resveratrol and hespertine work synergistically to increase glyoxalase levels.

The researchers gave 32 overweight or obese (BMI greater than 25) a combination of the two molecules – hesperetin 120 mg and trans-resveratrol 90 mg – daily for 8 weeks or placebo. Participants maintained the same diet and physical activity as before the study began. The researchers then analyzed their sugar levels and their arterial health.

The results show that in the participants with a BMI greater than 27.5, the two associated molecules – hesperetin and trans-resveratrol – increase the expression and activity of the enzyme Glo1 by 27% and decrease the concentration by 37% Methylglyoxal. In addition, participants receiving both molecules found a decrease in glucose levels, an improvement in insulin sensitivity and arterial function, and a decrease in vascular inflammation.

The authors point out, however, that although these results are encouraging, therapeutic doses of hesperetin and trans-resveratrol can not be achieved by diet.

A previous study had already shown that resveratrol could improve the bone health of obese people who suffered from a metabolic syndrome.

Resveratrol against cognitive decline

Researchers have studied the effects of resveratrol on memory performance and glucose metabolism in healthy seniors. They were also interested in its impact on the functioning of a region of the brain involved in memory: the hippocampus.

46 men and women aged 50-76 years were randomized into two equivalent groups: one received 200 mg daily resveratrol and the other a placebo for 26 weeks. Before and after this 26-week period, participants underwent memory tests consisting of retaining words over 30 min. The researchers also used brain imaging.

Resveratrol supplements were associated with significant improvements in memory tests compared to the placebo group. The supplements were also associated with an increase in the ties between certain areas of the hippocampus with an area of ​​the brain activated by the memorization processes in the cerebral cortex.

In another study, researchers have chosen to study the effect of resveratrol on the progression of Alzheimer’s disease. 119 participants with mild-to-moderate Alzheimer’s disease had either a placebo or increasing doses of resveratrol. Patients who were treated with resveratrol for 12 months had little or no change in beta-amyloid (Abeta40) levels in the blood or cerebrospinal fluid. In contrast, researchers found decreases in levels of beta-amyloid 40 in those who had taken placebo between the start and the end of the study.

A decrease in the level of Abeta40 is considered an aggravation of dementia and progression of Alzheimer’s disease; Yet we can not yet conclude from this study that the effects of treatment of resveratrol are beneficial, “explains the author of the study.

The researchers found that resveratrol and its major metabolites cross the blood-brain barrier and act on the central nervous system.

Resveratrol helps to fight cancer

According to one study, resveratrol has the ability to inhibit cancer cells in the pancreas.

To demonstrate this, researchers at the University of Rochester studied the behavior of two groups of cancer cells when subjected to radiation: one without resveratrol and the other with 50 mg / mL resveratrol. The results show that cells treated with resveratrol are more sensitive to chemotherapy.

The anti-cancer effect of resveratrol is associated with deterioration of mitochondrial function. Indeed, the mitochondria represent a source of energy for the cells that resveratrol will inhibit, which induces the death of cancer cells.

From, the more recent study shows that resveratrol retains its anti-cancer properties even once digested.



Xue M. Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation. Diabetes. 2016 May 11. pii: db160153. [Epub ahead of print]

Witte AV, Kerti L, Margulies DS, Flöel A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci. 2014 Jun 4;34(23):7862-70. doi: 10.1523/JNEUROSCI.0385-14.2014.

R. S. Turner, R. G. Thomas, S. Craft, C. H. van Dyck, J. Mintzer, B. A. Reynolds, J. B. Brewer, R. A. Rissman, R. Raman, P. S. Aisen. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology, 2015; DOI: 10.1212/WNL.0000000000002035

Paul Okunieff, Weimin Sun, Wei Wang, Jung Kim, Shanmin Yang, “Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment”, Advances in Experimental Medicine and Biology, 2008

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